Soman is considered one of the most successful models in India. His first significant work was as a model for Thackersey fabrics and he is perhaps best known for his part in Alisha Chinai's hit music video, Made in India.

Soman's films include 16 December, Pachaikili Muthucharam, Agni Varsha and Asoka. In 2007 he appeared in Bhram, Say Salaam India and Bheja Fry. In 2009 he acted in Sachin Kundalkar’s Marathi film Gandh. He has also acted in a number of English language and other foreign films, including Valley of flowers, The Flag and the Swedish film Arn – The Knight Templar. He portrays Saladin, the revered 12th-century Kurdish leader of the Arabs and Muslims; he also played the titular role in the Indian science fiction TV Series Captain Vyom in the mid 90's.

Milind who had previously produced, 'Rules-Pyaar Ka Superhit Formula' will also be producing a children's television serial called 'Ghost Bana Dost'.

As an actor:

As a producer:

Milind Soman and his ex-girlfriend Madhu Sapre was at the centre of much controversy in India, when the pair posed nude in a print ad for Tuff Shoes. The social service branch of the Mumbai police had registered a case in August 1995 after Sapre and Soman posed in the nude, wearing only shoes and a python wrapped around them, for the ad campaign. Another case was filed under the Wildlife Protection Act against the advertising agency for illegal use of the python. The accused include the publishers and distributors of two magazines that featured the controversial ad, the advertising agency, the two models and the photographers. The case lasted for 14 years, after which the courts acquitted the accused.